Pseudoginsenoside‐F11 alleviates oligomeric β‐amyloid‐induced endosome‐lysosome defects in microglia

IL-4-Induced Selective Clearance of Oligomeric -Amyloid Peptide1–42 by Rat Primary Type 2 Microglia

Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression

Microglia, the resident CNS macrophages, have been implicated in the pathogenesis of Rett Syndrome (RTT), an X-linked neurodevelopmental disorder. However, the mechanism by which microglia contribute to the disorder is unclear and recent data suggest that microglia do not play a causative role. Here, we use the retinogeniculate system to determine if and how microglia contribute to pathogenesis...

RecA K72R filament formation defects reveal an oligomeric RecA species involved in filament extension.

Using an ensemble approach, we demonstrate that an oligomeric RecA species is required for the extension phase of RecA filament formation. The RecA K72R mutant protein can bind but not hydrolyze ATP or dATP. When mixed with other RecA variants, RecA K72R causes a drop in the rate of ATP hydrolysis and has been used to study disassembly of hydrolysis-proficient RecA protein filaments. RecA K72R ...

Silicon alleviates salt stress in pistachio plants

In this work, the effects of silicon (Si) supplementation were studied in pistachio (Pistacia veraL. cv Ahmadaghaii) plants exposed to high salinity stress. Plants were grown in pots undercontrol and salt (EC=15 dS m-1) conditions without or with Si treatment (0.35 g Na2SiO3 Kg-1soil) under field conditions. Salt stress reduced the plants’ growth significantly in both –Si and+Si plants; however...

P108: Microglia in Traumatic Brain Injury

Microglia is one of the first innate immune components. These cells account about 5 to 10% of the entire adult brain cells and are activated by trauma. Complex-mediated inflammatory responses occur through cellular and molecular events during and after the traumatic brain injury (TBI). In-lesion area astrocytes, microglia, and damaged neurons begin to secrete cytokines and chemokines. Microglia...